| 2. Round | 12/02/2022 | Jorge Wilstermann | - | Blooming | 0:1 | ||||
| 3. Round | 19/02/2022 | Royal Pari | - | Blooming | 1:1 |  |
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| 4. Round | 26/02/2022 | Blooming | - | Universitario de Vinto | 5:0 | ||||
| 5. Round | 06/03/2022 | Independiente Petrolero | - | Blooming | 2:3 | |
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| 6. Round | 13/03/2022 | Oriente Petrolero | - | Blooming | 1:2 | |
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| 7. Round | 02/04/2022 | Blooming | - | Always Ready | 1:0 | ||||
| 8. Round | 10/04/2022 | Real Tomayapo | - | Blooming | 1:2 | ||||
| 9. Round | 16/04/2022 | Bolívar | - | Blooming | 6:0 | ||||
| 10. Round | 20/04/2022 | Blooming | - | Jorge Wilstermann | 3:3 | ||||
| 12. Round | 01/05/2022 | Universitario de Vinto | - | Blooming | 2:1 | ||||
| 13. Round | 09/05/2022 | Blooming | - | Oriente Petrolero | 1:2 | ||||
| 14. Round | 13/05/2022 | Blooming | - | Independiente Petrolero | 4:0 | ||||
| 15. Round | 15/05/2022 | Always Ready | - | Blooming | 3:0 | ||||
| 16. Round | 22/05/2022 | Blooming | - | Real Tomayapo | 2:1 |
Bolivia