| 1. Round | 25/07/2021 | Pumas UNAM [U20] | - | Atlas Guadalajara [U20] | 1:0 | ||||
| 2. Round | 31/07/2021 | CF Monterrey [U20] | - | Pumas UNAM [U20] | 3:1 | ||||
| 3. Round | 08/08/2021 | Pumas UNAM [U20] | - | Atlético San Luis [U20] | 5:3 | ||||
| 4. Round | 14/08/2021 | Pumas UNAM [U20] | - | Gallos Blancos [U20] | 1:4 | ||||
| 5. Round | 17/08/2021 | Club Necaxa [U20] | - | Pumas UNAM [U20] | 1:1 | ||||
| 6. Round | 22/08/2021 | Pumas UNAM [U20] | - | Puebla FC [U20] | 1:3 | ||||
| 7. Round | 29/08/2021 | Deportivo Toluca [U20] | - | Pumas UNAM [U20] | 2:2 | ||||
| 9. Round | 18/09/2021 | Mazatlán FC [U20] | - | Pumas UNAM [U20] | 2:1 |
Mexico