| 8. Round | 18/02/2018 | Club Tijuana | - | Pumas UNAM | 4:1 | ||||
| 9. Round | 25/02/2018 | Pumas UNAM | - | Deportivo Guadalajara | 1:1 | ||||
| 10. Round | 04/03/2018 | Club León | - | Pumas UNAM | 3:0 | ||||
| 14. Round | 08/04/2018 | CF Monterrey | - | Pumas UNAM | 2:1 | ||||
| 16. Round | 23/04/2018 | Santos Laguna | - | Pumas UNAM | 1:2 | ||||
| 17. Round | 29/04/2018 | Pumas UNAM | - | Gallos Blancos | 1:1 |
Spain