| 1. Round | 23/07/2018 | Santos Laguna | - | Lobos BUAP | 2:1 | ||||
| 2. Round | 29/07/2018 | Lobos BUAP | - | CD Veracruz | 2:0 | ||||
| 3. Round | 04/08/2018 | Club Necaxa | - | Lobos BUAP | 1:0 | ||||
| 4. Round | 11/08/2018 | Lobos BUAP | - | Atlas Guadalajara | 0:0 | ||||
| 5. Round | 19/08/2018 | CF Pachuca | - | Lobos BUAP | 3:0 | ||||
| 6. Round | 23/08/2018 | Lobos BUAP | - | CF Monterrey | 1:2 | ||||
| 7. Round | 26/08/2018 | Gallos Blancos | - | Lobos BUAP | 2:0 | ||||
| 8. Round | 02/09/2018 | Lobos BUAP | - | CF América | 0:2 | ||||
| 9. Round | 16/09/2018 | Pumas UNAM | - | Lobos BUAP | 4:2 | ||||
| 10. Round | 23/09/2018 | Club León | - | Lobos BUAP | 0:1 | ||||
| 11. Round | 30/09/2018 | Lobos BUAP | - | Monarcas Morelia | 3:1 | ||||
| 12. Round | 08/10/2018 | Puebla FC | - | Lobos BUAP | 2:2 | ||||
| 13. Round | 21/10/2018 | Lobos BUAP | - | Deportivo Guadalajara | 1:1 | ||||
| 14. Round | 28/10/2018 | UANL Tigres | - | Lobos BUAP | 2:2 | ||||
| 15. Round | 04/11/2018 | Lobos BUAP | - | Club Tijuana | 3:1 | ||||
| 16. Round | 10/11/2018 | Cruz Azul | - | Lobos BUAP | 2:1 | ||||
| 17. Round | 25/11/2018 | Lobos BUAP | - | Deportivo Toluca | 2:0 |
Spain