| Group H | 20/04/2023 | San Lorenzo | - | Fortaleza - CE | 0:2 | ||||
| Group H | 03/05/2023 | Palestino | - | San Lorenzo | 0:0 |  |
|||
| Group H | 24/05/2023 | Fortaleza - CE | - | San Lorenzo | 3:2 | ||||
| Group H | 09/06/2023 | San Lorenzo | - | Palestino | 0:0 | ||||
| Group H | 27/06/2023 | San Lorenzo | - | Estudiantes de Mérida | 4:1 |  |
|||
| Play-offs | 13/07/2023 | Independiente Medellín | - | San Lorenzo | 0:1 | |
|
||
| Play-offs | 20/07/2023 | San Lorenzo | - | Independiente Medellín | 2:0 | |
|
||
| Round of 16 | 03/08/2023 | San Lorenzo | - | São Paulo FC | 1:0 | |
|||
| Round of 16 | 10/08/2023 | São Paulo FC | - | San Lorenzo | 2:0 | |
Paraguay