| 2. Round | 10/04/2010 | Philadelphia Union | - | D.C. United | 3:2 |  |
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| 2. Round | 18/04/2010 | D.C. United | - | Chicago Fire | 0:2 | ||||
| 3. Round | 01/05/2010 | D.C. United | - | New York RB | 0:2 | ||||
| 3. Round | 06/05/2010 | D.C. United | - | Kansas City Wizards | 2:1 | ||||
| 3. Round | 09/05/2010 | FC Dallas | - | D.C. United | 1:0 | ||||
| 3. Round | 16/05/2010 | D.C. United | - | Colorado Rapids | 0:1 | |
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| 3. Round | 23/05/2010 | Houston Dynamo | - | D.C. United | 2:0 | ||||
| 3. Round | 30/05/2010 | D.C. United | - | CD Chivas | 3:2 |  |
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| 4. Round | 06/06/2010 | D.C. United | - | Real Salt Lake | 0:0 | ||||
| 4. Round | 11/06/2010 | Seattle Sounders | - | D.C. United | 2:3 | ||||
| 4. Round | 27/06/2010 | Columbus Crew | - | D.C. United | 2:0 | ||||
| 5. Round | 04/07/2010 | San Jose Earthquakes | - | D.C. United | 1:1 | ||||
| 5. Round | 11/07/2010 | New York RB | - | D.C. United | 0:0 | ||||
| 5. Round | 16/07/2010 | D.C. United | - | Seattle Sounders | 0:1 | ||||
| 6. Round | 08/08/2010 | New England Revolution | - | D.C. United | 1:0 | ||||
| 6. Round | 15/08/2010 | D.C. United | - | FC Dallas | 1:3 | ||||
| 6. Round | 30/08/2010 | CD Chivas | - | D.C. United | 1:0 |
USA