| 1. Round | 24/07/2022 | FK Druzhba | - | Dinamo Stavropol | 0:0 | ||||
| 2. Round | 30/07/2022 | FK SKA Rostov | - | FK Druzhba | 2:0 |  |
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| 3. Round | 07/08/2022 | FK Druzhba | - | FK Chayka | 0:1 | ||||
| 4. Round | 13/08/2022 | FK Yessentuki | - | FK Druzhba | 0:2 |  |
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| 5. Round | 21/08/2022 | FK Druzhba | - | Forte Taganrog | 1:2 | |
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| 6. Round | 27/08/2022 | Spartak Nalchik | - | FK Druzhba | 1:1 | |
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| 7. Round | 03/09/2022 | FK Druzhba | - | Rotor Volgograd | 3:3 | |
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| 10. Round | 25/09/2022 | Alania-2 Vladikavkaz | - | FK Druzhba | 1:3 | ||||
| 11. Round | 01/10/2022 | FK Druzhba | - | FK Mashuk KMV | 0:1 | ||||
| 12. Round | 08/10/2022 | FK Druzhba | - | FK Legion Dynamo Makhachkala | 1:0 | ||||
| 16. Round | 04/11/2022 | FK Druzhba | - | FK Yessentuki | 4:0 | ||||
| 17. Round | 09/11/2022 | Forte Taganrog | - | FK Druzhba | 2:1 | |
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| 19. Round | 11/03/2023 | Rotor Volgograd | - | FK Druzhba | 0:1 | |
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| 8. Round | 18/03/2023 | FK Biolog Novokubansk | - | FK Druzhba | 0:1 | |
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| 21. Round | 25/03/2023 | Kuban-Holding Pavlovskaya | - | FK Druzhba | 0:0 | ||||
| 24. Round | 15/04/2023 | FK Legion Dynamo Makhachkala | - | FK Druzhba | 1:1 | ||||
| 25. Round | 22/04/2023 | FK Druzhba | - | Chernomorets Novorossisk | 0:3 | |
Russia