| 1. Round | 17/07/2022 | MFK Skalica | - | MFK Ružomberok | 0:2 | ||||
| 2. Round | 24/07/2022 | MFK Ružomberok | - | FK Železiarne Podbrezová | 2:2 | ||||
| 3. Round | 31/07/2022 | Tatran Liptovský Mikuláš | - | MFK Ružomberok | 0:0 | ||||
| 4. Round | 06/08/2022 | Dukla Banská Bystrica | - | MFK Ružomberok | 2:3 | ||||
| 5. Round | 13/08/2022 | MFK Ružomberok | - | AS Trenčín | 0:0 | ||||
| 6. Round | 20/08/2022 | Zlaté Moravce | - | MFK Ružomberok | 2:2 | ||||
| 12. Round | 30/09/2022 | MFK Ružomberok | - | MFK Skalica | 2:0 | ||||
| 14. Round | 15/10/2022 | MFK Ružomberok | - | Tatran Liptovský Mikuláš | 1:1 | ||||
| 15. Round | 22/10/2022 | MFK Ružomberok | - | Dukla Banská Bystrica | 1:1 | ||||
| 18. Round | 13/11/2022 | Slovan Bratislava | - | MFK Ružomberok | 2:0 | ||||
| 11. Round | 24/11/2022 | FC DAC 1904 | - | MFK Ružomberok | 1:0 | ||||
| 17. Round | 27/11/2022 | MFK Ružomberok | - | Zlaté Moravce | 2:2 |
Slovakia