| 1. Round | 17/07/2022 | MFK Skalica | - | MFK Ružomberok | 0:2 | ||||
| 2. Round | 24/07/2022 | MFK Ružomberok | - | FK Železiarne Podbrezová | 2:2 | ||||
| 3. Round | 31/07/2022 | Tatran Liptovský Mikuláš | - | MFK Ružomberok | 0:0 | ||||
| 4. Round | 06/08/2022 | Dukla Banská Bystrica | - | MFK Ružomberok | 2:3 | ||||
| 5. Round | 13/08/2022 | MFK Ružomberok | - | AS Trenčín | 0:0 | ||||
| 6. Round | 20/08/2022 | Zlaté Moravce | - | MFK Ružomberok | 2:2 | ||||
| 7. Round | 28/08/2022 | MFK Ružomberok | - | Slovan Bratislava | 0:1 | ||||
| 8. Round | 31/08/2022 | MFK Zemplín Michalovce | - | MFK Ružomberok | 1:1 | ||||
| 9. Round | 04/09/2022 | MFK Ružomberok | - | Spartak Trnava | 3:2 | ||||
| 10. Round | 09/09/2022 | MFK Ružomberok | - | MŠK Žilina | 0:2 |  |
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| 12. Round | 30/09/2022 | MFK Ružomberok | - | MFK Skalica | 2:0 |  |
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| 13. Round | 07/10/2022 | FK Železiarne Podbrezová | - | MFK Ružomberok | 0:2 |  |
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| 15. Round | 22/10/2022 | MFK Ružomberok | - | Dukla Banská Bystrica | 1:1 | ||||
| 16. Round | 29/10/2022 | AS Trenčín | - | MFK Ružomberok | 0:0 | ||||
| 11. Round | 24/11/2022 | FC DAC 1904 | - | MFK Ružomberok | 1:0 | ||||
| 17. Round | 27/11/2022 | MFK Ružomberok | - | Zlaté Moravce | 2:2 | |
Slovakia