| 15. Round | 06/02/2021 | Saltillo FC | - | Reboceros de La Piedad | 2:2 | ||||
| 16. Round | 12/02/2021 | Gavilanes de Matamoros | - | Saltillo FC | 2:1 | ||||
| 17. Round | 20/02/2021 | Saltillo FC | - | Tuzos de la UAZ | 2:3 | ||||
| 18. Round | 06/03/2021 | Alacranes de Durango | - | Saltillo FC | 3:1 |  |
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| 19. Round | 13/03/2021 | Saltillo FC | - | Cimarrones de Sonora II | 1:0 | |
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| 20. Round | 20/03/2021 | Saltillo FC | - | Colima FC | 0:1 | ||||
| 21. Round | 03/04/2021 | Leones Negros II | - | Saltillo FC | 3:0 | ||||
| 22. Round | 10/04/2021 | Saltillo FC | - | Tecos Fútbol Club | 2:2 |
Mexico