1. Round | 18/07/2021 | Club Olimpia | - | River Plate | 1:3 | ||||
7. Round | 28/08/2021 | Club Olimpia | - | Sol de América | 0:1 | ||||
8. Round | 13/09/2021 | Libertad | - | Club Olimpia | 0:3 | ||||
9. Round | 21/09/2021 | Club Olimpia | - | Club Nacional | 1:2 | ||||
10. Round | 26/09/2021 | River Plate | - | Club Olimpia | 1:2 | ||||
11. Round | 02/10/2021 | Club Olimpia | - | 12 de Octubre de Itauguá | 1:2 | ||||
12. Round | 18/10/2021 | Guaireña FC | - | Club Olimpia | 0:2 |