2. Round | 18/01/2021 | Santos Laguna | - | UANL Tigres | 2:0 | ||||
4. Round | 01/02/2021 | Santos Laguna | - | CF América | 1:1 | ||||
8. Round | 01/03/2021 | Santos Laguna | - | FC Juárez | 3:2 | ||||
12. Round | 22/03/2021 | Santos Laguna | - | Club León | 1:2 | ||||
14. Round | 12/04/2021 | Gallos Blancos | - | Santos Laguna | 1:0 |