| 1. Round | 25/07/2010 | UANL Tigres | - | Gallos Blancos (old) | 0:1 | ||||
| 2. Round | 31/07/2010 | Gallos Blancos (old) | - | Atlas Guadalajara | 2:1 | ||||
| 3. Round | 08/08/2010 | Monarcas Morelia | - | Gallos Blancos (old) | 6:0 |  |
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| 4. Round | 14/08/2010 | Club Necaxa | - | Gallos Blancos (old) | 1:1 | |
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| 5. Round | 22/08/2010 | Gallos Blancos (old) | - | CF América | 0:1 | ||||
| 6. Round | 29/08/2010 | Deportivo Toluca | - | Gallos Blancos (old) | 2:0 | ||||
| 7. Round | 11/09/2010 | Gallos Blancos (old) | - | Santos Laguna | 5:2 | ||||
| 8. Round | 18/09/2010 | Cruz Azul | - | Gallos Blancos (old) | 3:0 | ||||
| 9. Round | 25/09/2010 | Gallos Blancos (old) | - | CF Monterrey | 0:0 | ||||
| 10. Round | 03/10/2010 | Puebla FC | - | Gallos Blancos (old) | 2:0 | ||||
| 11. Round | 09/10/2010 | Gallos Blancos (old) | - | Deportivo Guadalajara | 2:2 | |
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| 15. Round | 30/10/2010 | Gallos Blancos (old) | - | Pumas UNAM | 2:1 | ||||
| 16. Round | 07/11/2010 | CF Pachuca | - | Gallos Blancos (old) | 2:1 |  |
Uruguay