| 3. Round | 29/08/2021 | Royal Excel Mouscron | - | Waasland-Beveren | 0:4 | ||||
| 4. Round | 10/09/2021 | SK Deinze | - | Royal Excel Mouscron | 3:1 | ||||
| 5. Round | 18/09/2021 | Royal Excel Mouscron | - | Excelsior Virton | 1:1 | ||||
| 6. Round | 26/09/2021 | Royal Excel Mouscron | - | KVC Westerlo | 1:2 |  |
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| 7. Round | 02/10/2021 | Lierse Kempenzonen | - | Royal Excel Mouscron | 2:2 | ||||
| 23. Round | 06/03/2022 | Royal Excel Mouscron | - | RWD Molenbeek | 0:1 | ||||
| 26. Round | 03/04/2022 | Excelsior Virton | - | Royal Excel Mouscron | 2:0 | ||||
| 27. Round | 08/04/2022 | Royal Excel Mouscron | - | KVC Westerlo | 2:6 |
Italy