| 1. Round | 17/03/2018 | Rio Grande Valley FC | - | Saint Louis FC | 1:1 | ||||
| 3. Round | 06/05/2018 | Saint Louis FC | - | Portland Timbers 2 | 0:0 | ||||
| 3. Round | 13/05/2018 | Orange County SC | - | Saint Louis FC | 1:1 | ||||
| 3. Round | 27/05/2018 | Colorado Springs Switchbacks | - | Saint Louis FC | 3:0 |  |
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| 4. Round | 03/06/2018 | Saint Louis FC | - | Swope Park Rangers | 2:0 | ||||
| 4. Round | 10/06/2018 | Tulsa Roughnecks | - | Saint Louis FC | 0:3 | ||||
| 4. Round | 17/06/2018 | Saint Louis FC | - | Real Monarchs SLC | 0:1 | ||||
| 4. Round | 24/06/2018 | Sacramento Republic | - | Saint Louis FC | 2:2 | ||||
| 4. Round | 01/07/2018 | Saint Louis FC | - | Rio Grande Valley FC | 0:0 | ||||
| 5. Round | 08/07/2018 | Las Vegas Lights FC | - | Saint Louis FC | 1:0 | ||||
| 5. Round | 22/07/2018 | Saint Louis FC | - | Orange County SC | 2:2 |
USA