| 1. Round | 12/09/2021 | Fénix | - | Rentistas | 3:1 | ||||
| 2. Round | 18/09/2021 | Peñarol | - | Fénix | 0:0 |  |
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| 3. Round | 26/09/2021 | Fénix | - | Montevideo City Torque | 1:1 | ||||
| 4. Round | 02/10/2021 | Villa Española | - | Fénix | 1:2 | ||||
| 5. Round | 10/10/2021 | Fénix | - | Nacional | 1:2 | |
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| 7. Round | 20/10/2021 | Fénix | - | Liverpool | 1:1 | ||||
| 13. Round | 19/11/2021 | Fénix | - | Deportivo Maldonado | 2:1 | ||||
| 15. Round | 04/12/2021 | Montevideo Wanderers | - | Fénix | 1:1 |
Uruguay
Italy