| 8. Round | 15/09/2022 | Liverpool | - | Peñarol | 0:1 | ||||
| 9. Round | 18/09/2022 | Peñarol | - | Cerrito | 3:1 |  |
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| 11. Round | 02/10/2022 | Montevideo Wanderers | - | Peñarol | 0:2 | ||||
| 12. Round | 09/10/2022 | Peñarol | - | Plaza Colonia | 0:1 | ||||
| 13. Round | 12/10/2022 | Boston River | - | Peñarol | 2:1 | ||||
| 14. Round | 16/10/2022 | Peñarol | - | River Plate | 1:1 | ||||
| 15. Round | 22/10/2022 | Cerro Largo | - | Peñarol | 0:2 | |
Uruguay