| Group 1 | 12/02/2008 | Caracas FC | - | San Lorenzo | 2:0 |  |
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| Group 1 | 21/02/2008 | San Lorenzo | - | Cruzeiro | 0:0 | ||||
| Group 1 | 12/03/2008 | Real Potosí | - | San Lorenzo | 2:3 | |
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| Group 1 | 25/03/2008 | San Lorenzo | - | Real Potosí | 1:0 | ||||
| Group 1 | 04/04/2008 | Cruzeiro | - | San Lorenzo | 3:1 | ||||
| Group 1 | 16/04/2008 | San Lorenzo | - | Caracas FC | 3:0 | ||||
| Round of 16 | 30/04/2008 | San Lorenzo | - | River Plate | 2:1 | ||||
| Round of 16 | 09/05/2008 | River Plate | - | San Lorenzo | 2:2 | |
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| Quarter-finals | 15/05/2008 | San Lorenzo | - | LDU Quito | 1:1 | ||||
| Quarter-finals | 22/05/2008 | LDU Quito | - | San Lorenzo | 5:3 pso | |
Argentina