1. Round | 08/01/2022 | Club Tijuana [] | - | Club León [] | 3:2 | ||||
2. Round | 15/01/2022 | Club León [] | - | UANL Tigres [] | 1:3 | ||||
5. Round | 05/02/2022 | CF Monterrey [] | - | Club León [] | 1:0 | ||||
6. Round | 12/02/2022 | Club León [] | - | Atlético San Luis [] | 1:0 | ||||
7. Round | 18/02/2022 | Club León [] | - | Santos Laguna [] | 2:2 | ||||
8. Round | 26/02/2022 | Atlas Guadalajara [] | - | Club León [] | 4:1 | ||||
9. Round | 05/03/2022 | Club León [] | - | Mazatlán FC [] | 1:1 | ||||
10. Round | 12/03/2022 | UANL Tigres [] | - | Club León [] | 1:1 | ||||
12. Round | 26/03/2022 | Club León [] | - | Deportivo Guadalajara [] | 1:4 |