| 1. Round | 06/08/2021 | CS Sedan | - | FC Annecy | 1:1 | ||||
| 2. Round | 13/08/2021 | FC Annecy | - | Stade Lavallois | 1:0 | ||||
| 4. Round | 27/08/2021 | FC Annecy | - | US Boulogne | 2:0 | ||||
| 7. Round | 17/09/2021 | US Orléans | - | FC Annecy | 2:2 | ||||
| 9. Round | 04/10/2021 | FC Annecy | - | FC Villefranche Beaujolais | 2:0 | ||||
| 10. Round | 08/10/2021 | FC Bastia-Borgo | - | FC Annecy | 1:2 | ||||
| 12. Round | 26/10/2021 | US Avranches | - | FC Annecy | 2:0 | ||||
| 14. Round | 19/11/2021 | US Créteil-Lusitanos | - | FC Annecy | 0:1 | ||||
| 15. Round | 06/12/2021 | FC Annecy | - | LB Châteauroux | 0:0 | ||||
| 16. Round | 10/12/2021 | FC Sète | - | FC Annecy | 0:0 |
France