| 2. Round | 27/10/2021 | Espérance de Tunis | - | CS Sfaxien | 1:0 | ||||
| 3. Round | 31/10/2021 | US Ben Guerdane | - | CS Sfaxien | 0:1 | ||||
| 4. Round | 03/11/2021 | CS Sfaxien | - | US Tataouine | 1:0 | ||||
| 5. Round | 06/11/2021 | ES Hammam Sousse | - | CS Sfaxien | 0:0 | ||||
| 1. Round | 14/11/2021 | CS Sfaxien | - | ES Métlaoui | 2:0 |  |
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| 7. Round | 21/11/2021 | CS Hammam-Lif | - | CS Sfaxien | 1:2 | |
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| 8. Round | 03/03/2022 | ES Métlaoui | - | CS Sfaxien | 2:1 | ||||
| 12. Round | 06/04/2022 | CS Sfaxien | - | ES Hammam Sousse | 1:1 | ||||
| 13. Round | 10/04/2022 | CA Bizertin | - | CS Sfaxien | 2:0 | ||||
| 14. Round | 18/04/2022 | CS Sfaxien | - | CS Hammam-Lif | 2:0 |
Tunisia