| 2. Round | 01/08/2021 | FK Chayka | - | FK SKA Rostov | 0:1 | ||||
| 3. Round | 08/08/2021 | FK SKA Rostov | - | Anzhi Makhachkala | 0:1 | ||||
| 8. Round | 08/09/2021 | FK Dinamo Makhachkala | - | FK SKA Rostov | 0:1 | ||||
| 9. Round | 12/09/2021 | FK SKA Rostov | - | Rotor-2 Volgograd | 1:0 | ||||
| 10. Round | 20/09/2021 | FK Tuapse | - | FK SKA Rostov | 0:3 dec. |  |
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| 12. Round | 03/10/2021 | FK SKA Rostov | - | Dinamo Stavropol | 2:1 | |
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| 13. Round | 10/10/2021 | Chernomorets Novorossisk | - | FK SKA Rostov | 0:1 | ||||
| 15. Round | 23/10/2021 | FK Biolog Novokubansk | - | FK SKA Rostov | 1:3 | ||||
| 20. Round | 06/03/2022 | FK SKA Rostov | - | FK Druzhba | 1:0 | |
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| 21. Round | 13/03/2022 | Alania-2 Vladikavkaz | - | FK SKA Rostov | 0:4 | ||||
| 22. Round | 20/03/2022 | FK SKA Rostov | - | Kuban-Holding Pavlovskaya | 0:1 | ||||
| 24. Round | 03/04/2022 | FK SKA Rostov | - | FK Dinamo Makhachkala | 0:1 | ||||
| 25. Round | 11/04/2022 | Rotor-2 Volgograd | - | FK SKA Rostov | 0:7 | ||||
| 32. Round | 22/05/2022 | FK Legion Dynamo Makhachkala | - | FK SKA Rostov | 1:1 | ||||
| 33. Round | 29/05/2022 | FK SKA Rostov | - | FK Mashuk KMV | 6:3 | |
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| 34. Round | 05/06/2022 | Spartak Nalchik | - | FK SKA Rostov | 1:2 | |
Russia