| 1. Round | 29/07/2021 | CF Monterrey II | - | Cancún FC | 1:2 |  |
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| 3. Round | 13/08/2021 | CF Monterrey II | - | Tapatío | 2:0 |  |
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| 4. Round | 18/08/2021 | Venados FC | - | CF Monterrey II | 1:1 | |
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| 5. Round | 26/08/2021 | CF Monterrey II | - | Club Celaya | 1:0 | ||||
| 6. Round | 01/09/2021 | Alebrijes de Oaxaca | - | CF Monterrey II | 0:0 | ||||
| 8. Round | 16/09/2021 | Cimarrones de Sonora | - | CF Monterrey II | 1:2 | |
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| 10. Round | 28/09/2021 | Tepatitlán | - | CF Monterrey II | 1:1 | ||||
| 11. Round | 06/10/2021 | CF Monterrey II | - | Coyotes de Tlaxcala | 4:1 |  |
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| 16. Round | 11/11/2021 | Correcaminos UAT | - | CF Monterrey II | 2:1 | |
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| 17. Round | 16/11/2021 | CF Monterrey II | - | Atlético Morelia | 0:1 |
Mexico