| 1. Round | 24/07/2021 | FK SKA Rostov | - | Spartak Nalchik | 0:0 |  |
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| 2. Round | 01/08/2021 | Spartak Nalchik | - | Dinamo Stavropol | 0:1 | ||||
| 3. Round | 07/08/2021 | Chernomorets Novorossisk | - | Spartak Nalchik | 1:1 | ||||
| 4. Round | 15/08/2021 | Spartak Nalchik | - | FK Yessentuki | 2:1 | |
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| 5. Round | 18/08/2021 | FK Biolog Novokubansk | - | Spartak Nalchik | 1:0 | |
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| 6. Round | 29/08/2021 | Spartak Nalchik | - | FK Legion Dynamo Makhachkala | 1:1 | ||||
| 7. Round | 04/09/2021 | FK Mashuk KMV | - | Spartak Nalchik | 1:2 | ||||
| 12. Round | 03/10/2021 | Alania-2 Vladikavkaz | - | Spartak Nalchik | 1:5 | ||||
| 13. Round | 10/10/2021 | Spartak Nalchik | - | Kuban-Holding Pavlovskaya | 1:1 |
Russia
Moldova