| 4. Round | 22/09/2015 | Skoda Xanthi | - | Olympiakos Piraeus | 1:3 | ||||
| 5. Round | 26/09/2015 | Olympiakos Piraeus | - | PAS Giannina | 5:1 |  |
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| 6. Round | 04/10/2015 | PAOK Saloniki | - | Olympiakos Piraeus | 0:2 |  |
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| 7. Round | 17/10/2015 | Olympiakos Piraeus | - | AEK Athen | 4:0 | |
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| 8. Round | 25/10/2015 | Atromitos | - | Olympiakos Piraeus | 1:2 | |
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| 9. Round | 31/10/2015 | Veria FC | - | Olympiakos Piraeus | 0:2 | |
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| 13. Round | 05/12/2015 | Panthrakikos | - | Olympiakos Piraeus | 3:4 | ||||
| 14. Round | 13/12/2015 | Olympiakos Piraeus | - | Panetolikos | 1:0 | ||||
| 15. Round | 19/12/2015 | AEL Kalloni | - | Olympiakos Piraeus | 0:2 | ||||
| 19. Round | 23/01/2016 | Olympiakos Piraeus | - | Skoda Xanthi | 1:0 | |
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| 20. Round | 31/01/2016 | PAS Giannina | - | Olympiakos Piraeus | 0:3 | ||||
| 21. Round | 07/02/2016 | Olympiakos Piraeus | - | PAOK Saloniki | 1:0 | |
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| 22. Round | 13/02/2016 | AEK Athen | - | Olympiakos Piraeus | 1:0 |  |
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| 26. Round | 13/03/2016 | Olympiakos Piraeus | - | Panathinaikos | 3:1 | ||||
| 28. Round | 03/04/2016 | Olympiakos Piraeus | - | Panthrakikos | 4:0 | ||||
| 25. Round | 06/04/2016 | AEP Iraklis FC | - | Olympiakos Piraeus | 0:2 | |
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| 30. Round | 17/04/2016 | Olympiakos Piraeus | - | AEL Kalloni | 5:0 |
Spain