| 5. Round | 03/10/2021 | Olympiakos Piraeus | - | Panathinaikos | 0:0 |  |
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| 6. Round | 16/10/2021 | Panathinaikos | - | Ionikos Nikea | 4:1 | ||||
| 7. Round | 23/10/2021 | Asteras Tripolis | - | Panathinaikos | 2:1 | ||||
| 8. Round | 31/10/2021 | Panathinaikos | - | OFI Heraklion | 0:0 | ||||
| 9. Round | 07/11/2021 | Panathinaikos | - | PAOK Saloniki | 1:3 | ||||
| 10. Round | 22/11/2021 | Lamia | - | Panathinaikos | 1:3 | ||||
| 11. Round | 28/11/2021 | Panathinaikos | - | Panetolikos | 2:0 | ||||
| 12. Round | 05/12/2021 | AEK Athen | - | Panathinaikos | 1:0 | ||||
| 13. Round | 11/12/2021 | Panathinaikos | - | Atromitos | 2:0 | ||||
| 15. Round | 19/12/2021 | Panathinaikos | - | PAS Giannina | 2:0 | ||||
| 16. Round | 05/01/2022 | Panathinaikos | - | Aris Saloniki | 2:0 | ||||
| 17. Round | 09/01/2022 | Volos NFC | - | Panathinaikos | 3:1 | ||||
| 18. Round | 16/01/2022 | Panathinaikos | - | Olympiakos Piraeus | 0:0 | ||||
| 19. Round | 22/01/2022 | Ionikos Nikea | - | Panathinaikos | 0:1 | ||||
| 20. Round | 29/01/2022 | Panathinaikos | - | Asteras Tripolis | 0:1 | ||||
| 21. Round | 02/02/2022 | OFI Heraklion | - | Panathinaikos | 3:2 | ||||
| 22. Round | 06/02/2022 | PAOK Saloniki | - | Panathinaikos | 2:1 | |
Italy