| 13. Round | 09/10/2010 | Club Olimpia | - | Club Nacional | 1:2 | ||||
| 17. Round | 31/10/2010 | Cerro Porteño | - | Club Olimpia | 1:1 | ||||
| 18. Round | 06/11/2010 | 3 de Febrero | - | Club Olimpia | 0:3 |  |
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| 19. Round | 12/11/2010 | Club Olimpia | - | Sportivo Luqueño | 1:1 | ||||
| 21. Round | 27/11/2010 | Club Olimpia | - | Tacuary | 2:1 | |
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| 22. Round | 03/12/2010 | Club Olimpia | - | Sportivo Trinidense | 1:1 |
Paraguay