10. Round | 25/09/2021 | Puebla FC | - | Cruz Azul | 1:1 | ||||
11. Round | 29/09/2021 | Atlas Guadalajara | - | Puebla FC | 0:1 | ||||
13. Round | 16/10/2021 | Club Necaxa | - | Puebla FC | 0:1 | ||||
14. Round | 20/10/2021 | Puebla FC | - | Mazatlán FC | 2:0 | ||||
15. Round | 23/10/2021 | Puebla FC | - | Club León | 0:1 | ||||
16. Round | 30/10/2021 | FC Juárez | - | Puebla FC | 0:2 | ||||
17. Round | 06/11/2021 | Puebla FC | - | Deportivo Toluca | 1:0 |