| 9. Round | 18/09/2021 | Club Tijuana [U16] | - | Pumas UNAM [U16] | 1:0 | ||||
| 11. Round | 02/10/2021 | Deportivo Toluca [U16] | - | Club Tijuana [U16] | 2:0 | ||||
| 15. Round | 30/10/2021 | Club Tijuana [U16] | - | Gallos Blancos [U16] | 3:2 | ||||
| 16. Round | 06/11/2021 | FC Juárez [U16] | - | Club Tijuana [U16] | 1:3 | ||||
| 17. Round | 13/11/2021 | Pumas UNAM [U16] | - | Club Tijuana [U16] | 0:0 | ||||
| 18. Round | 20/11/2021 | Club Tijuana [U16] | - | Cruz Azul [U16] | 0:0 |
Mexico