| 1. Round | 14/08/2021 | İstanbulspor AŞ | - | Manisa FK | 3:4 | ||||
| 2. Round | 22/08/2021 | Ümraniyespor | - | İstanbulspor AŞ | 2:0 | ||||
| 3. Round | 29/08/2021 | İstanbulspor AŞ | - | Altınordu FK | 3:0 |  |
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| 5. Round | 16/09/2021 | İstanbulspor AŞ | - | MKE Ankaragücü | 0:1 | ||||
| 6. Round | 20/09/2021 | Boluspor | - | İstanbulspor AŞ | 1:1 | ||||
| 9. Round | 18/10/2021 | İstanbulspor AŞ | - | Tuzlaspor | 1:0 | ||||
| 13. Round | 20/11/2021 | Bursaspor | - | İstanbulspor AŞ | 2:4 | ||||
| 14. Round | 27/11/2021 | İstanbulspor AŞ | - | Denizlispor | 1:1 | ||||
| 15. Round | 04/12/2021 | BB Erzurumspor | - | İstanbulspor AŞ | 3:1 | ||||
| 17. Round | 16/12/2021 | Adanaspor | - | İstanbulspor AŞ | 1:0 | ||||
| 19. Round | 25/12/2021 | Bandırmaspor | - | İstanbulspor AŞ | 0:0 | ||||
| 20. Round | 09/01/2022 | Manisa FK | - | İstanbulspor AŞ | 1:2 | |
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| 22. Round | 22/01/2022 | Altınordu FK | - | İstanbulspor AŞ | 0:5 | |
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| 24. Round | 12/02/2022 | MKE Ankaragücü | - | İstanbulspor AŞ | 0:1 | ||||
| 25. Round | 16/02/2022 | İstanbulspor AŞ | - | Boluspor | 1:2 | ||||
| 28. Round | 06/03/2022 | Tuzlaspor | - | İstanbulspor AŞ | 0:2 |
Bosnia-Herzegovina