| 4. Round | 15/08/2010 | CF Monterrey | - | Pumas UNAM | 5:2 |  |
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| 5. Round | 22/08/2010 | CF Pachuca | - | CF Monterrey | 2:2 | |
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| 6. Round | 29/08/2010 | CF Monterrey | - | Jaguares Chiapas | 1:1 | ||||
| 7. Round | 12/09/2010 | UANL Tigres | - | CF Monterrey | 0:1 | |
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| 8. Round | 19/09/2010 | CF Monterrey | - | Atlas Guadalajara | 2:0 | |
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| 9. Round | 25/09/2010 | Gallos Blancos (old) | - | CF Monterrey | 0:0 | ||||
| 10. Round | 03/10/2010 | CF Monterrey | - | Club Necaxa | 2:1 | |
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| 11. Round | 10/10/2010 | CF América | - | CF Monterrey | 0:0 | ||||
| 12. Round | 17/10/2010 | CF Monterrey | - | Deportivo Toluca | 2:0 | ||||
| 13. Round | 24/10/2010 | Santos Laguna | - | CF Monterrey | 1:2 | |
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| 14. Round | 28/10/2010 | CF Monterrey | - | Cruz Azul | 2:4 | |
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| 16. Round | 07/11/2010 | Puebla FC | - | CF Monterrey | 2:0 | ||||
| 17. Round | 13/11/2010 | CF Monterrey | - | Deportivo Guadalajara | 2:3 | |
Mexico
Italy