| 2. Round | 11/02/2022 | Sportivo Ameliano | - | Resistencia SC | 1:4 |  |
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| 3. Round | 18/02/2022 | Resistencia SC | - | Club Nacional | 3:1 | ||||
| 5. Round | 05/03/2022 | Resistencia SC | - | Guaireña FC | 2:2 | ||||
| 6. Round | 12/03/2022 | Sol de América | - | Resistencia SC | 1:1 | ||||
| 13. Round | 29/04/2022 | Resistencia SC | - | Sportivo Ameliano | 3:0 | ||||
| 15. Round | 12/05/2022 | Resistencia SC | - | Guaraní | 1:2 | ||||
| 19. Round | 19/06/2022 | Club Olimpia | - | Resistencia SC | 6:1 |
Paraguay