| 7. Round | 20/08/2021 | Independiente II | - | Defensa y Justicia II | 1:1 | ||||
| 9. Round | 27/08/2021 | Arsenal de Sarandí II | - | Defensa y Justicia II | 0:1 | ||||
| 10. Round | 03/09/2021 | Defensa y Justicia II | - | Central Córdoba SdE II | 0:1 | ||||
| 11. Round | 09/09/2021 | Boca Juniors II | - | Defensa y Justicia II | 3:2 |  |
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| 12. Round | 20/09/2021 | Defensa y Justicia II | - | Banfield II | 0:2 |
Paraguay