| 2. Round | 12/02/2018 | Club Olimpia | - | General Díaz | 3:1 | ||||
| 3. Round | 16/02/2018 | General Díaz | - | Independiente de Campo Grande | 1:1 | ||||
| 14. Round | 27/04/2018 | Independiente de Campo Grande | - | General Díaz | 2:3 |  |
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| 15. Round | 06/05/2018 | Club Nacional | - | General Díaz | 3:1 | ||||
| 16. Round | 09/05/2018 | General Díaz | - | Sportivo Luqueño | 2:1 | ||||
| 17. Round | 14/05/2018 | Guaraní | - | General Díaz | 2:2 | ||||
| 18. Round | 19/05/2018 | General Díaz | - | Deportivo Santaní | 1:0 | ||||
| 19. Round | 27/05/2018 | Cerro Porteño | - | General Díaz | 4:1 | ||||
| 20. Round | 31/05/2018 | General Díaz | - | 3 de Febrero | 3:2 | ||||
| 21. Round | 04/06/2018 | Sol de América | - | General Díaz | 4:3 | |
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| 22. Round | 09/06/2018 | General Díaz | - | Libertad | 0:2 |
Paraguay
