| 1. Round | 19/09/2021 | CD Cuautla | - | Alebrijes de Oaxaca II | 4:2 | ||||
| 2. Round | 25/09/2021 | Club Calor | - | CD Cuautla | 1:1 | ||||
| 5. Round | 13/10/2021 | Lobos Huerta | - | CD Cuautla | 1:1 |  |
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| 6. Round | 17/10/2021 | CD Cuautla | - | Huracanes Izcalli | 3:0 | ||||
| 7. Round | 23/10/2021 | Club de Ciervos | - | CD Cuautla | 3:7 | |
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| 8. Round | 29/10/2021 | Alebrijes de Oaxaca II | - | CD Cuautla | 1:1 | ||||
| 9. Round | 07/11/2021 | CD Cuautla | - | Club Calor | 2:1 | |
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| 10. Round | 10/11/2021 | Aguacateros CDU | - | CD Cuautla | 0:0 |  |
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| 13. Round | 28/11/2021 | Huracanes Izcalli | - | CD Cuautla | 1:4 | |
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| 4. Round | 01/12/2021 | Guerreros Xico | - | CD Cuautla | 0:3 | ||||
| 14. Round | 05/12/2021 | CD Cuautla | - | Club de Ciervos | 4:1 | |
Mexico