| 1. Round | 09/03/2019 | Tacoma Defiance | - | Rio Grande Valley FC | 1:0 |  |
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| 1. Round | 17/03/2019 | Tacoma Defiance | - | Los Angeles Galaxy II | 0:3 | ||||
| 1. Round | 30/03/2019 | Tacoma Defiance | - | New Mexico United | 1:2 | ||||
| 2. Round | 11/04/2019 | Orange County SC | - | Tacoma Defiance | 4:0 | ||||
| 2. Round | 14/04/2019 | Las Vegas Lights FC | - | Tacoma Defiance | 5:0 | ||||
| 2. Round | 21/04/2019 | Phoenix Rising | - | Tacoma Defiance | 4:0 | ||||
| 3. Round | 12/05/2019 | Tacoma Defiance | - | Portland Timbers 2 | 1:4 | ||||
| 4. Round | 09/06/2019 | Colorado Springs Switchbacks | - | Tacoma Defiance | 3:0 | ||||
| 4. Round | 16/06/2019 | Austin Bold | - | Tacoma Defiance | 1:1 | ||||
| 5. Round | 07/07/2019 | Rio Grande Valley FC | - | Tacoma Defiance | 0:0 | ||||
| 5. Round | 13/07/2019 | Real Monarchs SLC | - | Tacoma Defiance | 5:0 | ||||
| 5. Round | 28/07/2019 | Tacoma Defiance | - | OKC Energy FC | 0:2 | ||||
| 6. Round | 10/08/2019 | Tacoma Defiance | - | Orange County SC | 2:1 | ||||
| 6. Round | 31/08/2019 | Tacoma Defiance | - | San Antonio FC | 5:1 | ||||
| 8. Round | 06/10/2019 | Fresno FC | - | Tacoma Defiance | 1:4 | ||||
| 8. Round | 17/10/2019 | New Mexico United | - | Tacoma Defiance | 1:1 |
Puerto Rico