1. Round | 26/02/2022 | Austin FC | - | FC Cincinnati | 5:0 | ||||
2. Round | 05/03/2022 | FC Cincinnati | - | D.C. United | 0:1 | ||||
2. Round | 13/03/2022 | Orlando City | - | FC Cincinnati | 1:2 | ||||
2. Round | 19/03/2022 | FC Cincinnati | - | Inter Miami CF | 3:1 | ||||
2. Round | 26/03/2022 | Charlotte FC | - | FC Cincinnati | 2:0 | ||||
3. Round | 02/04/2022 | FC Cincinnati | - | CF Montréal | 3:4 | ||||
3. Round | 16/04/2022 | Atlanta United FC | - | FC Cincinnati | 0:0 |