| Round of 16 | 07/04/2021 | Deportivo Saprissa | - | Philadelphia Union | 0:1 | ||||
| Round of 16 | 15/04/2021 | Philadelphia Union | - | Deportivo Saprissa | 4:0 | ||||
| Quarter-finals | 28/04/2021 | Atlanta United FC | - | Philadelphia Union | 0:3 | ||||
| Quarter-finals | 05/05/2021 | Philadelphia Union | - | Atlanta United FC | 1:1 | ||||
| Semi-finals | 13/08/2021 | CF América | - | Philadelphia Union | 2:0 | ||||
| Semi-finals | 16/09/2021 | Philadelphia Union | - | CF América | 0:2 |  |
USA
Colombia 