| 4. Round | 11/04/2021 | Jorge Wilstermann | - | The Strongest | 0:3 | ||||
| 5. Round | 26/04/2021 | Independiente Petrolero | - | Jorge Wilstermann | 5:4 |  |
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| 6. Round | 03/05/2021 | Atlético Palmaflor | - | Jorge Wilstermann | 3:1 |  |
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| 11. Round | 26/07/2021 | Jorge Wilstermann | - | Blooming | 2:1 | ||||
| 12. Round | 01/08/2021 | Bolívar | - | Jorge Wilstermann | 4:0 | ||||
| 13. Round | 06/08/2021 | Jorge Wilstermann | - | Club Aurora | 2:1 | ||||
| 14. Round | 08/08/2021 | Real Tomayapo | - | Jorge Wilstermann | 1:2 | ||||
| 17. Round | 22/08/2021 | Nacional Potosí | - | Jorge Wilstermann | 0:1 | ||||
| 22. Round | 20/10/2021 | Always Ready | - | Jorge Wilstermann | 0:0 | ||||
| 23. Round | 23/10/2021 | Jorge Wilstermann | - | Royal Pari | 4:1 | ||||
| 24. Round | 26/10/2021 | Real Potosí | - | Jorge Wilstermann | 2:2 |  |
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| 25. Round | 30/10/2021 | Jorge Wilstermann | - | CD Guabirá | 2:1 | ||||
| 26. Round | 21/11/2021 | Blooming | - | Jorge Wilstermann | 2:2 | ||||
| 27. Round | 28/11/2021 | Jorge Wilstermann | - | Bolívar | 1:0 | ||||
| 28. Round | 01/12/2021 | Club Aurora | - | Jorge Wilstermann | 1:1 | ||||
| 29. Round | 06/12/2021 | Jorge Wilstermann | - | Real Tomayapo | 3:0 | |
USA
Bolivia