| 2. Round | 15/03/2021 | Real Potosí | - | Club Aurora | 1:1 |  |
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| 1. Round | 21/03/2021 | Bolívar | - | Real Potosí | 1:0 | |
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| 3. Round | 02/04/2021 | Real Tomayapo | - | Real Potosí | 0:0 | ||||
| 4. Round | 12/04/2021 | Real Potosí | - | Club San José | 3:0 |  |
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| 6. Round | 02/05/2021 | Real Potosí | - | Nacional Potosí | 1:2 | |
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| 7. Round | 10/05/2021 | Oriente Petrolero | - | Real Potosí | 2:0 | ||||
| 5. Round | 12/05/2021 | Real Santa Cruz | - | Real Potosí | 4:1 | |
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| 19. Round | 17/09/2021 | Club San José | - | Real Potosí | 0:0 | ||||
| 20. Round | 22/09/2021 | Real Potosí | - | Real Santa Cruz | 3:0 | ||||
| 21. Round | 26/09/2021 | Nacional Potosí | - | Real Potosí | 4:2 | ||||
| 22. Round | 19/10/2021 | Real Potosí | - | Oriente Petrolero | 2:1 | |
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| 25. Round | 02/11/2021 | Atlético Palmaflor | - | Real Potosí | 0:1 | ||||
| 26. Round | 21/11/2021 | Real Potosí | - | Always Ready | 3:2 | ||||
| 27. Round | 28/11/2021 | Royal Pari | - | Real Potosí | 5:0 | ||||
| 28. Round | 02/12/2021 | Real Potosí | - | Independiente Petrolero | 0:5 | |
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| 29. Round | 05/12/2021 | Real Potosí | - | CD Guabirá | 1:3 | ||||
| 30. Round | 11/12/2021 | Blooming | - | Real Potosí | 1:0 |
Bolivia