| 1. Round | 24/07/2021 | Puebla FC [U16] | - | CF Pachuca [U16] | 2:3 | ||||
| 2. Round | 31/07/2021 | CF Pachuca [U16] | - | Cruz Azul [U16] | 1:2 | ||||
| 4. Round | 14/08/2021 | CF América [U16] | - | CF Pachuca [U16] | 0:1 | ||||
| 5. Round | 15/09/2021 | CF Pachuca [U16] | - | Pumas UNAM [U16] | 1:0 | ||||
| 9. Round | 18/09/2021 | CF Pachuca [U16] | - | Deportivo Toluca [U16] | 0:0 | ||||
| 10. Round | 25/09/2021 | Cruz Azul [U16] | - | CF Pachuca [U16] | 1:2 | ||||
| 11. Round | 02/10/2021 | CF Pachuca [U16] | - | Puebla FC [U16] | 1:1 | ||||
| 12. Round | 09/10/2021 | Pumas UNAM [U16] | - | CF Pachuca [U16] | 2:0 | ||||
| 13. Round | 16/10/2021 | CF Pachuca [U16] | - | FC Juárez [U16] | 4:1 | ||||
| 14. Round | 23/10/2021 | Club Tijuana [U16] | - | CF Pachuca [U16] | 0:1 | ||||
| 16. Round | 06/11/2021 | CF Pachuca [U16] | - | CF América [U16] | 3:1 | ||||
| 17. Round | 13/11/2021 | Deportivo Toluca [U16] | - | CF Pachuca [U16] | 4:1 |  |
Mexico