3. Round | 19/02/2022 | Cerro Porteño | - | Guaraní | 2:0 | ||||
4. Round | 26/02/2022 | Guaraní | - | Resistencia SC | 3:3 | ||||
9. Round | 10/04/2022 | Sportivo Ameliano | - | Guaraní | 0:1 | ||||
10. Round | 17/04/2022 | Guaraní | - | Club Nacional | 0:1 | ||||
11. Round | 20/04/2022 | Club Olimpia | - | Guaraní | 1:0 |