| 3. Round | 11/08/2012 | Independiente CG | - | Club Olimpia | 1:1 | ||||
| 4. Round | 19/08/2012 | Club Olimpia | - | Libertad | 2:2 | ||||
| 5. Round | 25/08/2012 | Sportivo Luqueño | - | Club Olimpia | 2:1 | ||||
| 7. Round | 01/09/2012 | Tacuary | - | Club Olimpia | 2:3 | ||||
| 6. Round | 09/09/2012 | Club Olimpia | - | Club Nacional | 1:0 | ||||
| 8. Round | 15/09/2012 | Club Olimpia | - | Guaraní | 0:1 | ||||
| 9. Round | 23/09/2012 | Cerro de Franco | - | Club Olimpia | 2:2 | ||||
| 10. Round | 30/09/2012 | Sol de América | - | Club Olimpia | 1:1 |  |
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| 11. Round | 07/10/2012 | Club Olimpia | - | Sportivo Carapeguá | 3:0 | ||||
| 12. Round | 21/10/2012 | Club Olimpia | - | Club Rubio Ñu | 3:2 | ||||
| 13. Round | 27/10/2012 | Cerro Porteño | - | Club Olimpia | 4:1 | ||||
| 14. Round | 31/10/2012 | Club Olimpia | - | Independiente CG | 3:1 | |
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| 18. Round | 21/11/2012 | Club Olimpia | - | Tacuary | 2:2 | ||||
| 19. Round | 24/11/2012 | Guaraní | - | Club Olimpia | 2:1 | |
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| 20. Round | 02/12/2012 | Club Olimpia | - | Cerro de Franco | 0:0 |
Uruguay