| 12. Round | 17/03/2022 | Tepatitlán | - | Pumas Tabasco | 1:0 | ||||
| 13. Round | 23/03/2022 | Pumas Tabasco | - | Cimarrones de Sonora | 2:2 | ||||
| 14. Round | 26/03/2022 | Cancún FC | - | Pumas Tabasco | 2:2 | ||||
| 15. Round | 31/03/2022 | Pumas Tabasco | - | Correcaminos UAT | 1:2 | ||||
| 16. Round | 05/04/2022 | Alebrijes de Oaxaca | - | Pumas Tabasco | 0:0 | ||||
| 17. Round | 14/04/2022 | Pumas Tabasco | - | Atlético Morelia | 0:1 |
Mexico