| 6. Round | 29/08/2021 | Forte Taganrog | - | FK Tuapse | 3:0 |  |
|||
| 8. Round | 08/09/2021 | Rotor-2 Volgograd | - | FK Tuapse | 0:1 | ||||
| 10. Round | 20/09/2021 | FK Tuapse | - | FK SKA Rostov | 0:3 dec. |  |
|||
| 14. Round | 18/10/2021 | FK Tuapse | - | FK Biolog Novokubansk | 0:3 dec. | ||||
| 15. Round | 23/10/2021 | FK Legion Dynamo Makhachkala | - | FK Tuapse | 0:1 | ||||
| 16. Round | 01/11/2021 | FK Tuapse | - | FK Mashuk KMV | 3:0 | ||||
| 17. Round | 05/11/2021 | Spartak Nalchik | - | FK Tuapse | 1:1 |  |
|||
| 18. Round | 12/11/2021 | FK Tuapse | - | Anzhi Makhachkala | 1:1 | ||||
| 19. Round | 19/11/2021 | FK Druzhba | - | FK Tuapse | 1:0 | ||||
| 20. Round | 08/03/2022 | Alania-2 Vladikavkaz | - | FK Tuapse | 1:4 | |
|
||
| 21. Round | 13/03/2022 | Kuban-Holding Pavlovskaya | - | FK Tuapse | 1:2 | ||||
| 22. Round | 21/03/2022 | FK Tuapse | - | Forte Taganrog | 0:3 | ||||
| 23. Round | 27/03/2022 | FK Dinamo Makhachkala | - | FK Tuapse | 3:0 | |
|||
| 27. Round | 22/04/2022 | FK Tuapse | - | Dinamo Stavropol | 2:1 | |
|||
| 29. Round | 06/05/2022 | FK Tuapse | - | FK Yessentuki | 3:0 | |
|||
| 34. Round | 05/06/2022 | FK Chayka | - | FK Tuapse | 5:0 |
Russia