| 5. Round | 15/08/2021 | FK Kolomna | - | SKA-Khabarovsk 2 | 2:4 | ||||
| 15. Round | 10/10/2021 | SKA-Khabarovsk 2 | - | FK Kolomna | 1:1 | ||||
| 16. Round | 14/10/2021 | FK Kolomna | - | FK Znamya Noginsk | 6:2 | ||||
| 17. Round | 19/10/2021 | FK Saransk | - | FK Kolomna | 5:1 | ||||
| 18. Round | 25/10/2021 | FK Kolomna | - | Kvant Obninsk | 0:2 | ||||
| 20. Round | 04/11/2021 | Rodina Moskva | - | FK Kolomna | 7:0 | ||||
| 21. Round | 10/11/2021 | FK Kolomna | - | FK Peresvet Podolsk | 3:2 |
Russia