| 22. Round | 20/03/2022 | Dinamo Moskva | - | FK Rostov | 1:1 | ||||
| 19. Round | 06/04/2022 | FK Rostov | - | Krylia Sovetov | 1:0 | ||||
| 24. Round | 10/04/2022 | FK Rostov | - | Lokomotiv Moskva | 4:1 | ||||
| 25. Round | 17/04/2022 | Arsenal Tula | - | FK Rostov | 1:2 | ||||
| 26. Round | 24/04/2022 | FK Rostov | - | Spartak Moskva | 3:2 | ||||
| 27. Round | 30/04/2022 | FK Krasnodar | - | FK Rostov | 2:1 |  |
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| 28. Round | 08/05/2022 | FK Ufa | - | FK Rostov | 0:0 |
Belarus