| 1. Round | 24/07/2021 | FK Khimki | - | Zenit St. Petersburg | 1:3 | ||||
| 2. Round | 01/08/2021 | FK Krasnodar | - | FK Khimki | 0:1 | ||||
| 3. Round | 08/08/2021 | FK Khimki | - | FK Rostov | 1:1 | ||||
| 4. Round | 16/08/2021 | FK Sochi | - | FK Khimki | 3:0 | ||||
| 5. Round | 22/08/2021 | FK Khimki | - | Rubin Kazan | 1:1 | ||||
| 7. Round | 11/09/2021 | Spartak Moskva | - | FK Khimki | 3:1 |  |
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| 8. Round | 18/09/2021 | FK Ufa | - | FK Khimki | 3:2 | |
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| 10. Round | 02/10/2021 | Arsenal Tula | - | FK Khimki | 0:0 | ||||
| 11. Round | 17/10/2021 | FK Khimki | - | Akhmat Grozny | 2:0 | ||||
| 12. Round | 22/10/2021 | Dinamo Moskva | - | FK Khimki | 4:1 | ||||
| 13. Round | 31/10/2021 | FK Khimki | - | FK Ural | 0:0 | ||||
| 14. Round | 06/11/2021 | Krylia Sovetov | - | FK Khimki | 3:0 | ||||
| 16. Round | 27/11/2021 | FK Khimki | - | FK Krasnodar | 3:3 | ||||
| 17. Round | 05/12/2021 | FK Khimki | - | Arsenal Tula | 1:2 | ||||
| 18. Round | 12/12/2021 | Akhmat Grozny | - | FK Khimki | 4:1 |  |
Russia