1. Round | 24/07/2021 | FK Yessentuki | - | FK Biolog Novokubansk | 0:5 | ||||
3. Round | 07/08/2021 | FK Biolog Novokubansk | - | FK Legion Dynamo Makhachkala | 0:0 | ||||
4. Round | 15/08/2021 | FK Mashuk KMV | - | FK Biolog Novokubansk | 2:0 | ||||
9. Round | 12/09/2021 | FK Biolog Novokubansk | - | Alania-2 Vladikavkaz | 5:3 | ||||
10. Round | 18/09/2021 | Kuban-Holding Pavlovskaya | - | FK Biolog Novokubansk | 2:1 | ||||
11. Round | 26/09/2021 | FK Biolog Novokubansk | - | Forte Taganrog | 0:0 | ||||
12. Round | 03/10/2021 | FK Dinamo Makhachkala | - | FK Biolog Novokubansk | 2:0 | ||||
13. Round | 10/10/2021 | FK Biolog Novokubansk | - | Rotor-2 Volgograd | 3:0 | ||||
14. Round | 18/10/2021 | FK Tuapse | - | FK Biolog Novokubansk | 0:3 dec. | ||||
15. Round | 23/10/2021 | FK Biolog Novokubansk | - | FK SKA Rostov | 1:3 |