| 2. Round | 25/07/2021 | FK Khimki 2 | - | Kvant Obninsk | 2:0 | ||||
| 4. Round | 07/08/2021 | Kvant Obninsk | - | SKA-Khabarovsk 2 | 3:0 |  |
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| 3. Round | 18/08/2021 | FK Strogino Moskva | - | Kvant Obninsk | 4:0 |  |
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| 6. Round | 21/08/2021 | FK Saransk | - | Kvant Obninsk | 3:0 | ||||
| 8. Round | 04/09/2021 | Kvant Obninsk | - | FK Kolomna | 2:0 | ||||
| 13. Round | 30/09/2021 | Kvant Obninsk | - | FK Strogino Moskva | 1:2 | ||||
| 14. Round | 04/10/2021 | SKA-Khabarovsk 2 | - | Kvant Obninsk | 3:0 | |
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| 15. Round | 10/10/2021 | FK Znamya Noginsk | - | Kvant Obninsk | 1:1 | |
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| 16. Round | 14/10/2021 | Kvant Obninsk | - | FK Saransk | 1:4 | ||||
| 18. Round | 25/10/2021 | FK Kolomna | - | Kvant Obninsk | 0:2 |
Russia